Bruno Canard Selected Research

DNA-Directed RNA Polymerases (RNA Polymerase)

1/2020	Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites.
1/2020	Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis.
9/2012	Chemical constituents of Anacolosa pervilleana and their antiviral activities.
5/2012	Biflavonoids of Dacrydium balansae with potent inhibitory activity on dengue 2 NS5 polymerase.
6/2009	A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.
3/2006	Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis.

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Bruno Canard Research Topics

Disease

9	Infections 10/2021 - 11/2002
9	Dengue (Dengue Fever) 10/2021 - 05/2007
6	COVID-19 01/2022 - 01/2020
6	Severe Acute Respiratory Syndrome 01/2021 - 03/2006
4	Diarrhea 06/2009 - 10/2005
2	Viremia 10/2021 - 01/2021
2	Virus Diseases (Viral Diseases) 01/2020 - 01/2020
1	Lymphocytic Choriomeningitis 01/2022
1	Stroke (Strokes) 01/2021
1	Disease Resistance 01/2021
1	Zika Virus Infection 01/2020
1	Fever (Fevers) 01/2017
1	Microcephaly 01/2017
1	Nervous System Diseases (Neurological Disorders) 01/2017
1	Guillain-Barre Syndrome 01/2017
1	Myocarditis (Carditis) 12/2016
1	Enterovirus Infections 04/2013
1	Yellow Fever 05/2007
1	Hepatitis C 02/2005
1	Acquired Immunodeficiency Syndrome (AIDS) 02/2005
1	RNA Virus Infections 08/2004

Drug/Important Bio-Agent (IBA)

14	Antiviral Agents (Antivirals)IBA 04/2021 - 10/2005
8	RNA (Ribonucleic Acid)IBA 01/2021 - 02/2005
6	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 01/2020 - 03/2006
6	NucleosidesIBA 01/2020 - 11/2002
5	NucleotidesIBA 10/2021 - 05/2012
5	Viral RNAIBA 01/2020 - 06/2009
4	VaccinesIBA 10/2021 - 05/2007
4	Proteins (Proteins, Gene)FDA Link 01/2020 - 04/2006
3	Pharmaceutical PreparationsIBA 05/2021 - 04/2013
3	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)IBA 01/2021 - 02/2005
3	ethyl acetateIBA 09/2012 - 04/2012
2	AT-511IBA 01/2022 - 01/2021
2	ProdrugsIBA 10/2021 - 01/2021
2	GuanosineIBA 10/2021 - 01/2021
2	remdesivirIBA 04/2021 - 01/2021
2	EndoribonucleasesIBA 04/2006 - 03/2006
1	ExoribonucleasesIBA 01/2022
1	AT-752IBA 10/2021
1	SimeprevirIBA 05/2021
1	Protease Inhibitors (Protease Inhibitor)IBA 05/2021
1	Interferon Type IIBA 01/2021
1	Immunologic Factors (Immunomodulators)IBA 01/2021
1	nasIBA 01/2020
1	favipiravirIBA 01/2017
1	Peptide Hydrolases (Proteases)FDA Link 12/2016
1	podocarpusflavone AIBA 05/2012
1	BiflavonoidsIBA 05/2012
1	Viral DNAIBA 02/2012
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 02/2012
1	AminesIBA 06/2009
1	ProteomeIBA 04/2008
1	acridoneIBA 04/2006
1	UridineIBA 04/2006
1	2'-O-methylguanosine 5'-triphosphateIBA 02/2005
1	Guanosine Triphosphate (GTP)IBA 02/2005
1	Ribavirin (Virazole)FDA LinkGeneric 08/2004

Therapy/Procedure

6	Therapeutics 10/2021 - 02/2005
1	Drug Therapy (Chemotherapy) 05/2012